Synthesis and antitumor activity of some analogues of flavone acetic acid

P Valenti; G Fabbri; A Rampa; A Bisi; S Gobbi; P Da Re; M Carrara; A Sgevano; L Cima

Synthesis and antitumor activity of some analogues of flavone acetic acid

Anticancer Drug Des. 1996 Apr;11(3):243-52.

Authors

P Valenti¹, G Fabbri, A Rampa, A Bisi, S Gobbi, P Da Re, M Carrara, A Sgevano, L Cima

Affiliation

¹ Department of Pharmaceutical Sciences, University of Bologna, Italy.

PMID: 8663911

Abstract

Some coumarin-, flavonol- and flavanon-acetic acids are described. The cytotoxicity of the synthesized compounds was determined on a human colon carcinoma cell line (LoVo) through evaluation of neutral red uptake, performed by the Riddel method. All tested derivatives were able to induce a statistically significant reduction of lysosomal neutral red uptake at 5 x 10(-5) M concentration. Some compounds were more active than the reference compound flavon-8-acetic acid.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Acetates / chemical synthesis*
Acetates / therapeutic use
Antineoplastic Agents / chemical synthesis*
Antineoplastic Agents / therapeutic use
Colonic Neoplasms / drug therapy*
Coumarins / chemical synthesis
Coumarins / therapeutic use
Flavonoids / chemical synthesis*
Flavonoids / therapeutic use
Humans
Structure-Activity Relationship
Tumor Cells, Cultured

Substances

Acetates
Antineoplastic Agents
Coumarins
Flavonoids