2-Diazopyrroles: synthesis and antileukemic activity

Farmaco. 1996 Apr;51(4):275-7.

Abstract

The title compounds were synthesised in preparative yields by diazotization of the corresponding 2-aminopyrroles. In preliminary screening tests as antileukemic agents they showed modest activity against the murine and human leukemic cell lines FLC and K562S and their multidrug-resistant daunorubicin selected sublines.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antineoplastic Agents / chemical synthesis*
  • Antineoplastic Agents / pharmacology
  • Humans
  • Leukemia / drug therapy*
  • Mice
  • Pyrroles / chemical synthesis*
  • Pyrroles / pharmacology
  • Tumor Cells, Cultured

Substances

  • Antineoplastic Agents
  • Pyrroles