Abstract
The relation between viremia and clinical outcome in individuals infected with human immunodeficiency virus-type 1 (HIV-1) has important implications for therapeutic research and clinical care. HIV-1 RNA in plasma was quantified with a branched-DNA signal amplification assay as a measure of viral load in a cohort of 180 seropositive men studied for more than 10 years. The risk of acquired immunodeficiency syndrome (AIDS) and death in study subjects, including those with normal numbers of CD4+ T cells, was directly related to plasma viral load at study entry. Plasma viral load was a better predictor of progression to AIDS and death than was the number of CD4+ T cells.
Publication types
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Comment
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Acquired Immunodeficiency Syndrome / virology*
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Antiviral Agents / therapeutic use
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Biomarkers / blood
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CD4 Lymphocyte Count
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CD4-Positive T-Lymphocytes / virology
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Cohort Studies
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Disease Progression
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Follow-Up Studies
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HIV Infections / drug therapy
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HIV Infections / mortality
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HIV Infections / virology*
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HIV-1 / genetics
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HIV-1 / physiology*
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Humans
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Male
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Prognosis
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Proportional Hazards Models
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RNA, Viral / blood*
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Survival Rate
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Time Factors
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Viremia / virology*
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Virus Replication
Substances
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Antiviral Agents
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Biomarkers
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RNA, Viral