Abstract
T1/ST2 is a receptor-like molecule homologous to the type I interleukin-1 receptor. Despite this sequence similarity, we have been unable to demonstrate binding of T1/ST2 to any of the three interleukin-1 species. In searching for a ligand for T1/ST2, we have cloned a cell surface protein to which it binds. This protein is unable to initiate signal transduction by the T1/ST2 receptor in several in vitro assays.
MeSH terms
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3T3 Cells
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Amino Acid Sequence
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Animals
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Cell Line
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Cloning, Molecular
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DNA / metabolism
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Female
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Humans
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Interleukin-1 Receptor-Like 1 Protein
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Interleukin-8 / genetics
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Kinetics
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Membrane Proteins*
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Mice
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Molecular Sequence Data
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NF-kappa B / metabolism
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Organ Specificity
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Promoter Regions, Genetic
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Protein Biosynthesis
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Proteins / metabolism*
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Rats
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Receptors, Cell Surface
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Receptors, Interleukin
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Receptors, Interleukin-1 / biosynthesis
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Receptors, Interleukin-1 / chemistry
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Receptors, Interleukin-1 / metabolism*
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Recombinant Proteins / biosynthesis
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Recombinant Proteins / chemistry
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Recombinant Proteins / metabolism
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Sequence Homology, Amino Acid
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Substrate Specificity
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Tumor Cells, Cultured
Substances
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IL1RL1 protein, human
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Il1rl1 protein, mouse
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Interleukin-1 Receptor-Like 1 Protein
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Interleukin-8
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Membrane Proteins
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NF-kappa B
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Proteins
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Receptors, Cell Surface
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Receptors, Interleukin
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Receptors, Interleukin-1
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Recombinant Proteins
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DNA
Associated data
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GENBANK/U41804
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GENBANK/U41805