Ten patients affected with HCV-related chronic hepatitis received alpha lymphoblastoid-IFN, 3 mU i.m. TW, for 12 months. We obtained: 4 complete responses, 5 partial responses, 1 non-response (therapy stopped after 3 months). During the fourteen months follow-up, 4 patients (1 complete responder, 3 partial responders) relapsed.