Serological comparison of type A foot and mouth disease virus isolates from Thailand

Rev Sci Tech. 1995 Sep;14(3):547-55. doi: 10.20506/rst.14.3.852.

Abstract

Antigenic variation of type A foot and mouth disease (FMD) virus in Thailand was examined using a total of 82 field viruses isolated between 1986 and 1989. A two-dimensional serum microneutralisation test was used to compare these isolates to a reference strain, A15 Bangkok 1960 (A BKK/60). Viruses regarded as unrelated to A BKK/60 were compared to another reference strain, A22 Nakhon Pathom 1986 (A NPT/86). This approach divided the viruses into two groups. Most of the viruses shared a close antigenic relationship with A BKK/60. Only twelve viruses were regarded as unrelated to A BKK/60, and these were related to A NPT/86. All but one of these twelve isolates were from two provinces in one administrative region of the country. Future type A vaccines in Thailand will need to confer protection against both groups of viruses.

Keywords: Aphtovirus; Foot and mouth disease virus type A; Serological comparison; Thailand.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antigenic Variation
  • Antigens, Viral / analysis*
  • Aphthovirus / classification
  • Aphthovirus / immunology*
  • Aphthovirus / isolation & purification
  • Buffaloes
  • Cattle
  • Foot-and-Mouth Disease / virology*
  • Immune Sera / immunology
  • Neutralization Tests / veterinary
  • Rabbits
  • Sheep
  • Swine
  • Thailand

Substances

  • Antigens, Viral
  • Immune Sera