Structural analysis of antiviral sulfated alpha-D-(1-->3)-linked mannans

Carbohydr Res. 1995 Aug 25;273(2):179-85. doi: 10.1016/0008-6215(95)00078-8.

Abstract

The structures of two alpha-(1-->3)-alpha-D-xylo-mannans were determined. The different antiviral activity of the xylo-mannans from Nothogenia fastigiata was explained on the basis of a flexible backbone, molecular size, content and distribution of sulfate groups and of the single stubs of beta-(1-->2)-linked D-xylose.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antiviral Agents / chemistry*
  • Antiviral Agents / isolation & purification
  • Antiviral Agents / pharmacology
  • Carbohydrate Conformation
  • Herpesvirus 1, Human / drug effects
  • Magnetic Resonance Spectroscopy
  • Mannans / chemistry*
  • Mannans / isolation & purification
  • Mannans / pharmacology
  • Methylation
  • Molecular Weight
  • Monosaccharides / analysis
  • Optical Rotation
  • Seaweed / chemistry*
  • Spectroscopy, Fourier Transform Infrared
  • Sulfuric Acid Esters / chemistry*
  • Sulfuric Acid Esters / isolation & purification
  • Sulfuric Acid Esters / pharmacology
  • Xylose / chemistry

Substances

  • Antiviral Agents
  • Mannans
  • Monosaccharides
  • Sulfuric Acid Esters
  • Xylose