A 62-year-old female patient consulted for a suppurative-hemorrhagic nasal condition 18 months evolution. Exploration found granulomatous rhinitis which was producing septal perforation and histology compatible with necrotizing granulomatous vasculitis, fulfilling the diagnostic criteria for focal Wegener's granulomatosis, in view of the absence of lung and renal damage. Treatment with trimethoprim-sulfamethoxazole alone described in the medical literature as an option for this process, yielded excellent results with remission of symptoms and normalization of the exploration.