The effect of vasopressin analogue [d(CH2)5(1),Tyr(Me)2]AVP on memory process in rats with experimental amnesia

Acta Neurobiol Exp (Wars). 1995;55(3):207-11. doi: 10.55782/ane-1995-1077.

Abstract

We investigated the effect of a single 2 micrograms dose of vasopressin (AVP) analogue [(CH2)5(1),Tyr(Me)2]AVP on the processes of retrieval of conditioned reflexes in rats with experimentally induced amnesia. The models used were: electroconvulsive shock (ECS) and hypoxia. It severely impaired the memory processes. The AVP analogue [d(CH2)5(1),Tyr(Me)2]AVP facilitated retrieval of passive avoidance in all animals.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Arginine Vasopressin / administration & dosage
  • Arginine Vasopressin / analogs & derivatives*
  • Arginine Vasopressin / pharmacology
  • Conditioning, Classical / drug effects
  • Electroshock
  • Hypoxia, Brain / psychology
  • Injections, Intraventricular
  • Male
  • Memory / drug effects*
  • Memory Disorders / psychology*
  • Rats
  • Rats, Wistar

Substances

  • Arginine Vasopressin
  • argipressin, beta-mercapto-beta,beta cyclopentamethylenepropionic acid(1)-