Abstract
We investigated the effect of a single 2 micrograms dose of vasopressin (AVP) analogue [(CH2)5(1),Tyr(Me)2]AVP on the processes of retrieval of conditioned reflexes in rats with experimentally induced amnesia. The models used were: electroconvulsive shock (ECS) and hypoxia. It severely impaired the memory processes. The AVP analogue [d(CH2)5(1),Tyr(Me)2]AVP facilitated retrieval of passive avoidance in all animals.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Arginine Vasopressin / administration & dosage
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Arginine Vasopressin / analogs & derivatives*
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Arginine Vasopressin / pharmacology
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Conditioning, Classical / drug effects
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Electroshock
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Hypoxia, Brain / psychology
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Injections, Intraventricular
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Male
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Memory / drug effects*
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Memory Disorders / psychology*
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Rats
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Rats, Wistar
Substances
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Arginine Vasopressin
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argipressin, beta-mercapto-beta,beta cyclopentamethylenepropionic acid(1)-