Abstract
Liver necrosis was produced in rats by administering 3 doses o a mixture o carbon tetrachloide+olive oil, 2 ml/kg, ip. The liver damage was evidenced by the elevated levels serun aspartate aminotrans ferase (AST), alanine aminotransferase (AIT) and gamma glutamyl transpeptidase (gamma-GT) and by histopathological observations of liver sections. Nitrendipine, nimodipine and nisoldipine (1 mg/100 g of rat, ip) significantly reduced these elevated levels of AST, AIT and gamma-GT. Carbon tetrachloride induced liver necrosis was also found to be significantly reduced in nitrendipine, nimodipine and nisoldipine pre-treated animals as observed macroscopically and histologically.
MeSH terms
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Alanine Transaminase / blood
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Animals
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Aspartate Aminotransferases / blood
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Calcium Channel Blockers / therapeutic use*
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Carbon Tetrachloride Poisoning / pathology
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Carbon Tetrachloride Poisoning / prevention & control*
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Chemical and Drug Induced Liver Injury / metabolism
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Chemical and Drug Induced Liver Injury / pathology
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Chemical and Drug Induced Liver Injury / prevention & control*
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Liver / metabolism
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Liver / pathology*
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Male
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Necrosis / pathology
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Nimodipine / therapeutic use
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Nisoldipine / therapeutic use
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Nitrendipine / therapeutic use
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Rats
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Rats, Wistar
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gamma-Glutamyltransferase / blood
Substances
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Calcium Channel Blockers
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Nisoldipine
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Nimodipine
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Nitrendipine
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gamma-Glutamyltransferase
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Aspartate Aminotransferases
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Alanine Transaminase