An unusual rearrangement product formed during production of mometasone furoate (Sch 32088)

M S Puar; P A Thompson; M Ruggeri; D Beiner; A T McPhail

doi:10.1016/0039-128x(95)00035-o

An unusual rearrangement product formed during production of mometasone furoate (Sch 32088)

Steroids. 1995 Sep;60(9):612-4. doi: 10.1016/0039-128x(95)00035-o.

Authors

M S Puar¹, P A Thompson, M Ruggeri, D Beiner, A T McPhail

Affiliation

¹ Schering-Plough Research Institute, Kenilworth, New Jersey 07033-0539, USA.

PMID: 8545849
DOI: 10.1016/0039-128x(95)00035-o

Abstract

The structure of an unusual rearrangement product obtained during the production of mometasone furoate (Sch 32088) was assigned on the basis of NMR and X-ray crystallography data.

MeSH terms

Administration, Topical
Anti-Inflammatory Agents / chemical synthesis
Crystallography, X-Ray
Glucocorticoids
Magnetic Resonance Spectroscopy
Molecular Structure
Mometasone Furoate
Pregnadienediols / chemical synthesis*
Pregnadienediols / chemistry
Pregnatrienes / chemical synthesis*
Pregnatrienes / chemistry

Substances

9,21-dichloro-20-((2'-furanylcarbonyl)oxy)-11-hydroxy-16,17-dimethyl-18-norpregna-1,4,13,20-tetraen-3-one
Anti-Inflammatory Agents
Glucocorticoids
Pregnadienediols
Pregnatrienes
Mometasone Furoate