Abstract
The rpoB gene encodes the beta subunit of the DNA-dependent RNA polymerase of bacteria. Mutations in defined areas result in resistance to rifampin. Mycobacterium smegmatis is naturally resistant to rifampin, but analysis of the rpoB gene revealed no identifiable rifampin resistance mutations. Another mechanism of resistance may be present.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Amino Acid Sequence
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Antitubercular Agents / pharmacology
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Cloning, Molecular
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DNA-Directed DNA Polymerase / genetics*
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DNA-Directed DNA Polymerase / metabolism*
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Drug Resistance, Microbial
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Genes, Bacterial / genetics*
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Molecular Sequence Data
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Mycobacterium / drug effects*
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Mycobacterium / genetics*
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Rifampin / pharmacology
Substances
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Antitubercular Agents
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DNA-Directed DNA Polymerase
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Rifampin