Abstract
DNA mismatch-repair systems exist that repair mispaired bases formed during DNA replication, genetic recombination and as a result of damage to DNA. Some components of these systems are conserved in prokaryotes and eukaryotes. Genetic defects in mismatch-repair genes play an important role in common cancer-susceptibility syndromes and sporadic cancers.
Publication types
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Adaptor Proteins, Signal Transducing
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Adenosine Triphosphatases*
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Bacterial Proteins
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Base Composition
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Carrier Proteins
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Colorectal Neoplasms, Hereditary Nonpolyposis / genetics
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DNA Repair*
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Escherichia coli / genetics
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Escherichia coli Proteins*
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Fungal Proteins
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Genetic Predisposition to Disease
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Humans
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Models, Genetic
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MutL Protein Homolog 1
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MutL Proteins
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Mutation
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Neoplasm Proteins
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Neoplasms / genetics*
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Nuclear Proteins
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Saccharomyces cerevisiae / genetics
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Saccharomyces cerevisiae Proteins
Substances
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Adaptor Proteins, Signal Transducing
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Bacterial Proteins
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Carrier Proteins
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Escherichia coli Proteins
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Fungal Proteins
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MLH1 protein, S cerevisiae
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MLH1 protein, human
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MutL protein, E coli
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Neoplasm Proteins
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Nuclear Proteins
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Saccharomyces cerevisiae Proteins
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Adenosine Triphosphatases
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MutL Protein Homolog 1
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MutL Proteins