Abstract
Cyclic ADP-ribose is generated from NAD+ in glucose-stimulated beta-cells by CD38. Cyclic ADP-ribose mobilizes Ca2+ from the endoplasmic reticulum to secrete insulin. The amino acid residues of Cys-119 and Cys-201 in CD38 are essential for the synthesis and hydrolysis of cyclic ADP-ribose.
MeSH terms
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ADP-ribosyl Cyclase
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ADP-ribosyl Cyclase 1
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Adenosine Diphosphate Ribose / analogs & derivatives*
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Adenosine Diphosphate Ribose / metabolism
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Amino Acid Sequence
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Animals
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Antigens, CD / chemistry
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Antigens, CD / metabolism
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Antigens, Differentiation / chemistry
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Antigens, Differentiation / metabolism*
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Aplysia / enzymology
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Cyclic ADP-Ribose
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Endoplasmic Reticulum / physiology
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Glucose / pharmacology
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Humans
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Insulin / metabolism
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Insulin Secretion
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Islets of Langerhans / drug effects
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Islets of Langerhans / metabolism
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Islets of Langerhans / physiology
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Membrane Glycoproteins
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Mice
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Models, Biological
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Molecular Sequence Data
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N-Glycosyl Hydrolases / chemistry
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N-Glycosyl Hydrolases / metabolism*
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NAD / metabolism*
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Poly Adenosine Diphosphate Ribose / metabolism*
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Rats
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Sequence Homology, Amino Acid
Substances
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Antigens, CD
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Antigens, Differentiation
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Insulin
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Membrane Glycoproteins
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NAD
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Cyclic ADP-Ribose
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Adenosine Diphosphate Ribose
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Poly Adenosine Diphosphate Ribose
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N-Glycosyl Hydrolases
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ADP-ribosyl Cyclase
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CD38 protein, human
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Cd38 protein, mouse
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Cd38 protein, rat
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ADP-ribosyl Cyclase 1
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Glucose