New aspects of the physiological significance of NAD, poly ADP-ribose and cyclic ADP-ribose

Biochimie. 1995;77(5):356-63. doi: 10.1016/0300-9084(96)88146-6.

Abstract

Cyclic ADP-ribose is generated from NAD+ in glucose-stimulated beta-cells by CD38. Cyclic ADP-ribose mobilizes Ca2+ from the endoplasmic reticulum to secrete insulin. The amino acid residues of Cys-119 and Cys-201 in CD38 are essential for the synthesis and hydrolysis of cyclic ADP-ribose.

Publication types

  • Comparative Study
  • Review

MeSH terms

  • ADP-ribosyl Cyclase
  • ADP-ribosyl Cyclase 1
  • Adenosine Diphosphate Ribose / analogs & derivatives*
  • Adenosine Diphosphate Ribose / metabolism
  • Amino Acid Sequence
  • Animals
  • Antigens, CD / chemistry
  • Antigens, CD / metabolism
  • Antigens, Differentiation / chemistry
  • Antigens, Differentiation / metabolism*
  • Aplysia / enzymology
  • Cyclic ADP-Ribose
  • Endoplasmic Reticulum / physiology
  • Glucose / pharmacology
  • Humans
  • Insulin / metabolism
  • Insulin Secretion
  • Islets of Langerhans / drug effects
  • Islets of Langerhans / metabolism
  • Islets of Langerhans / physiology
  • Membrane Glycoproteins
  • Mice
  • Models, Biological
  • Molecular Sequence Data
  • N-Glycosyl Hydrolases / chemistry
  • N-Glycosyl Hydrolases / metabolism*
  • NAD / metabolism*
  • Poly Adenosine Diphosphate Ribose / metabolism*
  • Rats
  • Sequence Homology, Amino Acid

Substances

  • Antigens, CD
  • Antigens, Differentiation
  • Insulin
  • Membrane Glycoproteins
  • NAD
  • Cyclic ADP-Ribose
  • Adenosine Diphosphate Ribose
  • Poly Adenosine Diphosphate Ribose
  • N-Glycosyl Hydrolases
  • ADP-ribosyl Cyclase
  • CD38 protein, human
  • Cd38 protein, mouse
  • Cd38 protein, rat
  • ADP-ribosyl Cyclase 1
  • Glucose