[Preparation of aryloxyaminopropanol derivatives with potential effects on the cardiovascular system]

Ceska Slov Farm. 1995 Oct;44(5):261-4.
[Article in Czech]

Abstract

The synthesis of nine compounds belonging to the group of aryloxyaminopropanols with carbamate substitutions of the aromatic ring is described and pharmacologically evaluated. The results suggest that an addition of N-phenyl-piperazine derivatives to the main basic moiety can exert a positive influence on their beta-adrenolytic, antiarrhytmic or antihypertensive activity.

Publication types

  • English Abstract

MeSH terms

  • Animals
  • Cardiovascular Agents / chemical synthesis*
  • Cardiovascular Agents / chemistry
  • Guinea Pigs
  • In Vitro Techniques
  • Muscle Contraction / drug effects
  • Piperazines / chemical synthesis*
  • Piperazines / chemistry
  • Propanolamines / chemical synthesis*
  • Propanolamines / chemistry

Substances

  • Cardiovascular Agents
  • Piperazines
  • Propanolamines