Dialysis arthropathy (DA) and carpal tunnel syndrome are debilitating complications caused by dialysis-associated amyloidosis. They arise after several years of hemodialysis with cuprophane and their onset can be delayed with the use of high-flux dialysis. Serum C-reactive protein is elevated in patients with dialysis arthropathy, indicative of inflammatory processes. X-rays show periarticular bone cysts and erosive spondyloarthropathy. High-flux dialysis improves DA, but transplantation remains the best treatment.