Tuberous sclerosis is a disease characterized by the presence of hamartomatous nodules in various organs, including the brain. Thirteen CT scans and four MR investigations were performed in 13 patients. CT is superior to MR in demonstrating the presence of subependymal nodules, thereby confirming or establishing the diagnosis of tuberous sclerosis. MR is superior to CT in demonstrating the peripheral lesions, which are characterized by a long T2-relaxation time. Differentiation between cortical tubers and subcortical lesions is not yet accurate.