Managing resistant depression. When patients do not respond to therapy

Can Fam Physician. 1993 Apr:39:843-50.

Abstract

Many factors can influence outcome in the management of depressive illness, a major public health problem with significant associated mortality and morbidity. Two-thirds of patients will respond to antidepressants. The remainder can be treated in other ways. Only about 7% of patients are absolutely treatment resistant, and even they can be helped.

Publication types

  • Review

MeSH terms

  • Antidepressive Agents / administration & dosage
  • Antidepressive Agents / therapeutic use
  • Clinical Protocols
  • Comorbidity
  • Decision Trees
  • Depressive Disorder / diagnosis
  • Depressive Disorder / epidemiology
  • Depressive Disorder / therapy*
  • Drug Therapy, Combination
  • Electroconvulsive Therapy
  • Family Practice / methods*
  • Humans
  • Lithium / administration & dosage
  • Lithium / therapeutic use
  • Prevalence
  • Recurrence
  • Risk Factors
  • Treatment Failure

Substances

  • Antidepressive Agents
  • Lithium