Loxoprofen--another NSAID associated with acute asthmatic death

J Toxicol Clin Toxicol. 1993;31(2):333-40. doi: 10.3109/15563659309000400.

Abstract

Loxoprofen sodium (sodium 2[4-(2-oxocyclopentylmethyl) phenyl] dehydrate; CAS #68767-14-6) is a nonsteroidal, inflammatory drug marketed only in Japan. A case report describes its association with an acute asthmatic death with features resembling those evoked by similar drugs. The analytic methodology is reported. The blood levels of loxoprofen were in the therapeutic range. The tissue concentrations are reported.

Publication types

  • Case Reports

MeSH terms

  • Anti-Inflammatory Agents, Non-Steroidal / adverse effects*
  • Anti-Inflammatory Agents, Non-Steroidal / blood
  • Anti-Inflammatory Agents, Non-Steroidal / pharmacokinetics
  • Asthma / chemically induced*
  • Asthma / mortality
  • Chromatography, Gas
  • Gas Chromatography-Mass Spectrometry
  • Humans
  • Male
  • Middle Aged
  • Phenylpropionates / adverse effects*
  • Phenylpropionates / blood
  • Phenylpropionates / pharmacokinetics
  • Tissue Distribution

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Phenylpropionates
  • loxoprofen