Abstract
The synthesis of some amidic derivatives of N-methyl-isoquinolin-1(2H)-one-4-carboxylic acid and of isocoumarin-4-carboxylic acid are reported. These compounds have been evaluated for analgesic, antiinflammatory and antipyretic activities. The central nervous system effects have been also investigated.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amides / chemical synthesis*
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Amides / pharmacology
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Amides / toxicity
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Animals
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Anti-Inflammatory Agents, Non-Steroidal / chemical synthesis*
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Anti-Inflammatory Agents, Non-Steroidal / pharmacology
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Anti-Inflammatory Agents, Non-Steroidal / toxicity
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Anticonvulsants / pharmacology
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Behavior, Animal / drug effects
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Central Nervous System / drug effects
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Coumarins / chemical synthesis*
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Coumarins / pharmacology
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Coumarins / toxicity
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Edema / chemically induced
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Edema / prevention & control
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Ethanol / pharmacology
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Isoquinolines / chemical synthesis*
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Isoquinolines / pharmacology
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Isoquinolines / toxicity
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Lethal Dose 50
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Male
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Mice
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Pain Measurement / drug effects
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Parasympatholytics / pharmacology
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Peritonitis / chemically induced
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Peritonitis / prevention & control
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Rats
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Rats, Sprague-Dawley
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Spectrophotometry, Infrared
Substances
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Amides
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Anti-Inflammatory Agents, Non-Steroidal
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Anticonvulsants
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Coumarins
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Isoquinolines
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Parasympatholytics
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Ethanol