The role of c-myc in cell growth

Curr Opin Genet Dev. 1993 Feb;3(1):44-9. doi: 10.1016/s0959-437x(05)80339-9.

Abstract

Recent experiments have established that the c-myc oncogene encodes a sequence-specific DNA-binding protein that interacts with a specific intracellular partner, Max, and probably manifests its effects through transcriptional modulation. In addition, the range of biological functions attributed to expression of c-myc has grown to include not only transformation and mitogenesis but also cell death.

Publication types

  • Review

MeSH terms

  • Animals
  • Apoptosis / genetics
  • Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
  • Basic-Leucine Zipper Transcription Factors
  • Cell Division / genetics*
  • Cell Transformation, Neoplastic / genetics
  • Cell Transformation, Neoplastic / metabolism
  • DNA-Binding Proteins / metabolism
  • Gene Expression Regulation*
  • Genes, myc*
  • Humans
  • Interphase
  • Mitosis / genetics
  • Proto-Oncogene Proteins c-myc / physiology*
  • Transcription Factors / physiology*
  • Transcription, Genetic

Substances

  • Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
  • Basic-Leucine Zipper Transcription Factors
  • DNA-Binding Proteins
  • MAX protein, human
  • Myc associated factor X
  • Proto-Oncogene Proteins c-myc
  • Transcription Factors