Abstract
Recent experiments have established that the c-myc oncogene encodes a sequence-specific DNA-binding protein that interacts with a specific intracellular partner, Max, and probably manifests its effects through transcriptional modulation. In addition, the range of biological functions attributed to expression of c-myc has grown to include not only transformation and mitogenesis but also cell death.
MeSH terms
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Animals
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Apoptosis / genetics
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Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
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Basic-Leucine Zipper Transcription Factors
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Cell Division / genetics*
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Cell Transformation, Neoplastic / genetics
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Cell Transformation, Neoplastic / metabolism
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DNA-Binding Proteins / metabolism
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Gene Expression Regulation*
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Genes, myc*
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Humans
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Interphase
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Mitosis / genetics
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Proto-Oncogene Proteins c-myc / physiology*
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Transcription Factors / physiology*
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Transcription, Genetic
Substances
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Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
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Basic-Leucine Zipper Transcription Factors
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DNA-Binding Proteins
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MAX protein, human
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Myc associated factor X
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Proto-Oncogene Proteins c-myc
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Transcription Factors