Abstract
The novel 9a,11-cyclic carbamates (13-15) of 9-deoxo-9a-aza-9a-homoerythromycin A (4) have been prepared and characterized by 1H-1H and 1H-13C 2D NMR spectroscopy. When compared to azithromycin (1) or its 6-O-methyl derivative (2), the new bicyclic 15-membered azalides exhibited substantially decreased antibacterial activities in vitro.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Azithromycin / analogs & derivatives*
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Azithromycin / chemistry
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Azithromycin / pharmacology
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Bacteria / drug effects*
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Erythromycin / analogs & derivatives*
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Erythromycin / chemistry
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Erythromycin / pharmacology
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Magnetic Resonance Spectroscopy
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Microbial Sensitivity Tests
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Structure-Activity Relationship
Substances
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Erythromycin
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Azithromycin
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9-deoxy-9a-aza-9a-methyl-9a-homoerythromycin A