Abstract
Antibodies to ACTH1-24 detected by radioimmunoassay were present in the serum of a child with opsoclonus-myoclonus for at least 24 weeks after discontinuation of chronic ACTH treatment. The antibody-bound ACTH did not interfere with cortisol secretion. Six other children with opsoclonus-myoclonus and 16 control sera, including patients with chronically elevated endogenous ACTH, did not exhibit autoantibodies to ACTH. Antibodies to ACTH should be sought in patients who develop tolerance to ACTH treatment. The indirect but not direct ACTH assay method is sensitive to the presence of ACTH antibodies.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Adolescent
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Adrenocorticotropic Hormone / blood
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Adrenocorticotropic Hormone / immunology*
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Adrenocorticotropic Hormone / therapeutic use
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Antibodies, Monoclonal
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Autoantibodies / analysis*
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Child
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Child, Preschool
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Drug Tolerance
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Female
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Humans
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Immunoglobulin G / immunology
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Male
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Myoclonus / blood
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Myoclonus / drug therapy
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Myoclonus / immunology*
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Ocular Motility Disorders / blood
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Ocular Motility Disorders / drug therapy
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Ocular Motility Disorders / immunology*
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Radioimmunoassay
Substances
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Antibodies, Monoclonal
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Autoantibodies
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Immunoglobulin G
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Adrenocorticotropic Hormone