Abstract
The 4,5-dihydro-tetrazolo[5,1-d]-1,5-benzothiazepines 3a-k and the 5-phenyl-s-triazolo[3,4-d]-1,5-benzothiazepines 6a-f and 11a-c have been prepared and tested for their ability to displace [3H] flunitrazepam binding from bovine brain membranes. Some of the triazoloderivatives showed moderate binding affinity for the benzodiazepine receptor.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Binding Sites
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Binding, Competitive
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Brain / metabolism
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Cattle
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Flunitrazepam / metabolism
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Receptors, GABA-A / metabolism
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Structure-Activity Relationship
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Thiazepines / chemical synthesis*
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Thiazepines / chemistry
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Thiazepines / metabolism
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Triazoles / chemical synthesis*
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Triazoles / chemistry
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Triazoles / metabolism
Substances
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Receptors, GABA-A
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Thiazepines
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Triazoles
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Flunitrazepam