Abstract
Analysis was made of ALL treatment results according program POG 8493 in 9 infants. In 4 children WBC exceeded 100.0 G/l, and in 5 children CNS was affected. Eight infants had remission, six had relapse (mainly BM): early up to 8 month in 5, late--in 52 month in one girl. Four children died after relapse, four are still living: 2 I RC (2 and 23 months), 2 in II RC (1 month and 23 month). Probability of 4-year EFS was 0.25 and that survival--0.44. In view of continuing poor ALL prognosis, in infants it is necessary to look for more effective methods of treatment.
MeSH terms
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
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Asparaginase / administration & dosage
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Cortisone / analogs & derivatives
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Cyclophosphamide / administration & dosage
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Cytarabine / administration & dosage
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Dexamethasone / administration & dosage
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Doxorubicin / administration & dosage
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Drug Administration Schedule
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Female
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Humans
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Infant
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Male
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Mercaptopurine / administration & dosage
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Methotrexate / administration & dosage
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Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy*
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Precursor Cell Lymphoblastic Leukemia-Lymphoma / mortality
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Prednisone / administration & dosage
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Remission Induction
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Survival Rate
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Vincristine / administration & dosage
Substances
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Cytarabine
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Vincristine
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Dexamethasone
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Doxorubicin
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Cyclophosphamide
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Mercaptopurine
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Asparaginase
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Cortisone
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Prednisone
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Methotrexate
Supplementary concepts
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BFM-ALL 81 protocol
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POG 8493 protocol