Induction of alloxan/streptozotocin diabetes in dogs: a revised experimental technique

H R Anderson; A W Stitt; T A Gardiner; S J Lloyd; D B Archer

doi:10.1258/002367793780745426

Induction of alloxan/streptozotocin diabetes in dogs: a revised experimental technique

Lab Anim. 1993 Jul;27(3):281-5. doi: 10.1258/002367793780745426.

Authors

H R Anderson¹, A W Stitt, T A Gardiner, S J Lloyd, D B Archer

Affiliation

¹ Department of Ophthalmology, Queen's University of Belfast, UK.

PMID: 8366676
DOI: 10.1258/002367793780745426

Abstract

The diabetic dog represents an excellent model for use in many aspects of diabetic research. The present paper describes, in detail, a reproducible experimental protocol for the successful induction of chemical diabetes in beagles using a combination of the 2 pancreatic beta-cell cytoxic agents alloxan and streptozotocin.

MeSH terms

Alloxan
Animals
Blood Glucose / drug effects*
Blood Glucose / metabolism
Diabetes Mellitus, Experimental / blood
Diabetes Mellitus, Experimental / chemically induced*
Disease Models, Animal
Dogs
Glucose / administration & dosage
Reproducibility of Results
Streptozocin
Thymol / administration & dosage

Substances

Blood Glucose
Hartman's solution
Thymol
Streptozocin
Alloxan
Glucose