Abstract
Familial lupoid thrombocytopenia affecting three subjects in three generations is reported. All subjects had antinuclear antibodies with or without antibodies to single-stranded DNA, an increase in platelet-associated IgG, and a family member with an autoimmune disease. These findings implicate a genetic contribution. All subjects shared a common HLA haplotype.
MeSH terms
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Adult
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Antibodies, Antinuclear / analysis
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Antibodies, Antinuclear / immunology
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Autoimmune Diseases / genetics
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Blood Platelets / immunology
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DNA, Single-Stranded / immunology
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Enzyme-Linked Immunosorbent Assay
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Family Health*
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Female
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Fluorescent Antibody Technique
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HLA Antigens / genetics
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Haplotypes
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Humans
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Immunoglobulin G / analysis
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Lupus Erythematosus, Systemic / complications
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Lupus Erythematosus, Systemic / immunology
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Male
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Middle Aged
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Pedigree
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Thrombocytopenia / diagnosis
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Thrombocytopenia / genetics*
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Thrombocytopenia / immunology
Substances
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Antibodies, Antinuclear
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DNA, Single-Stranded
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HLA Antigens
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Immunoglobulin G