Thioguanine-induced adrenocortical necrosis and its prevention by hypophysectomy in the rat. Light and electron microscopic study

Exp Mol Pathol. 1977 Feb;26(1):155-68. doi: 10.1016/0014-4800(77)90074-0.
No abstract available

MeSH terms

  • Adrenal Cortex Diseases / chemically induced*
  • Adrenal Cortex Diseases / pathology
  • Adrenal Cortex Diseases / prevention & control
  • Adrenal Gland Diseases / chemically induced*
  • Animals
  • Capillary Permeability
  • Dose-Response Relationship, Drug
  • Endothelium / pathology
  • Female
  • Hemorrhage / chemically induced
  • Horseradish Peroxidase / metabolism
  • Hypophysectomy*
  • Microscopy, Electron
  • Necrosis
  • Rats
  • Thioguanine / toxicity*

Substances

  • Horseradish Peroxidase
  • Thioguanine