Splenectomy due to splenic abscess is without doubt an unusual occurrence, especially in Western countries. The paper reports the case of 19-year-old male who underwent splenectomy because of an abscess caused by Salmonella typhi. Following a revision of the literature it appears that only six cases of splenic abscess by S. typhi have been reported since 1940. Splenectomy represents the elective treatment for patients with splenic abscess provoked by any cause.