Abstract
(S)-9-(3-Hydroxy-2-phosphonylmethoxypropyl)adenine (HPMPA) and (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine (HPMPC) were tested in a mouse model for equine herpesvirus 1-induced abortion. HPMPA, given twice daily, reduced virus replication, but the compound was embryotoxic. A single dose of HPMPC, however, reduced the incidence of abortion and transfer of virus to the fetuses while producing no obvious toxic effects.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Abortion, Spontaneous / microbiology*
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Adenine / analogs & derivatives*
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Adenine / therapeutic use
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Adenine / toxicity
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Animals
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Antiviral Agents / chemical synthesis*
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Antiviral Agents / pharmacology
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Cidofovir
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Cytosine / analogs & derivatives*
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Cytosine / therapeutic use
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Cytosine / toxicity
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Female
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Herpesviridae Infections / microbiology
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Herpesviridae Infections / prevention & control*
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Herpesvirus 1, Equid*
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Mice
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Mice, Inbred BALB C
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Organophosphonates*
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Organophosphorus Compounds / therapeutic use*
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Organophosphorus Compounds / toxicity
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Pregnancy
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Virus Replication / drug effects
Substances
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Antiviral Agents
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Organophosphonates
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Organophosphorus Compounds
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Cytosine
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9-(S)-(3-hydroxy-2-(phosphonomethoxy)propyl)adenine
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Adenine
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Cidofovir