Effects of phosphonylmethoxyalkyl derivatives studied with a murine model for abortion induced by equine herpesvirus 1

Antimicrob Agents Chemother. 1993 Nov;37(11):2478-82. doi: 10.1128/AAC.37.11.2478.

Abstract

(S)-9-(3-Hydroxy-2-phosphonylmethoxypropyl)adenine (HPMPA) and (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine (HPMPC) were tested in a mouse model for equine herpesvirus 1-induced abortion. HPMPA, given twice daily, reduced virus replication, but the compound was embryotoxic. A single dose of HPMPC, however, reduced the incidence of abortion and transfer of virus to the fetuses while producing no obvious toxic effects.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Abortion, Spontaneous / microbiology*
  • Adenine / analogs & derivatives*
  • Adenine / therapeutic use
  • Adenine / toxicity
  • Animals
  • Antiviral Agents / chemical synthesis*
  • Antiviral Agents / pharmacology
  • Cidofovir
  • Cytosine / analogs & derivatives*
  • Cytosine / therapeutic use
  • Cytosine / toxicity
  • Female
  • Herpesviridae Infections / microbiology
  • Herpesviridae Infections / prevention & control*
  • Herpesvirus 1, Equid*
  • Mice
  • Mice, Inbred BALB C
  • Organophosphonates*
  • Organophosphorus Compounds / therapeutic use*
  • Organophosphorus Compounds / toxicity
  • Pregnancy
  • Virus Replication / drug effects

Substances

  • Antiviral Agents
  • Organophosphonates
  • Organophosphorus Compounds
  • Cytosine
  • 9-(S)-(3-hydroxy-2-(phosphonomethoxy)propyl)adenine
  • Adenine
  • Cidofovir