Analysis of sister chromatid exchange, micronucleus and chromosomal aberration frequencies in rodents exposed to mosquito coil smoke by inhalation route

M V Moorthy; P B Murthy

doi:10.1016/0378-4274(94)90130-9

Analysis of sister chromatid exchange, micronucleus and chromosomal aberration frequencies in rodents exposed to mosquito coil smoke by inhalation route

Toxicol Lett. 1994 Feb 15;70(3):357-62. doi: 10.1016/0378-4274(94)90130-9.

Authors

M V Moorthy¹, P B Murthy

Affiliation

¹ Department of Toxicology, Frederick Institute of Plant Protection and Toxicology, Padappai, India.

PMID: 8284803
DOI: 10.1016/0378-4274(94)90130-9

Abstract

Mosquito coil smoke emitting from a mosquito repellent, was tested for its mutagenic effect in bone marrow cells from mouse and rat after 4 h acute inhalation exposure. Coil smoke with suspended particulate concentrations of 99-129 mg/m3, significantly elevated the frequencies of sister chromatid exchanges in bone marrow cells and micronuclei in polychromatic erythrocytes. Analysis of chromosomal aberrations in metaphases also revealed a significantly higher incidence of chromosomal aberration frequency in exposed rats and mice.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Administration, Inhalation
Animals
Bone Marrow / drug effects
Bone Marrow Cells
Chromosome Aberrations*
Erythrocytes / drug effects
Insect Repellents / toxicity*
Metaphase
Mice
Micronuclei, Chromosome-Defective*
Micronucleus Tests
Rats
Rats, Wistar
Sister Chromatid Exchange*
Smoke / adverse effects*

Substances

Insect Repellents
Smoke