Because of inconsistency often found between in vitro testing and in vivo performance, a new restorative bonding system was evaluated by the placement of restorations in vivo in teeth to be extracted. The microleakage was determined following extraction after 3 months of clinical service. In each of the sample teeth, two restorations were placed on the labial surface, one in the middle of the enamel portion and the other extending over the cementoenamel portion. The results of this pilot study indicated that bonding to conditioned enamel with the new adhesive material is effective, and bonding to conditioned dentin appears to be clinically adequate.