Abstract
The novel 7-fluoro-4-chromone-3-sulfur compounds 5-12 were synthesized from the sulfinic acid 4, which can be obtained from the enaminone 3 and thionyl chloride. Especially the Flosequinane-like sulfoxide 12 was prepared and the vasodilating activity was evaluated in isolated ring segments of rat aorta.
MeSH terms
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Animals
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Aorta, Thoracic / drug effects
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Chromones / chemical synthesis*
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Chromones / pharmacology
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In Vitro Techniques
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Male
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Muscle, Smooth, Vascular / drug effects
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Rats
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Rats, Wistar
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Vasodilator Agents / chemical synthesis*
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Vasodilator Agents / pharmacology
Substances
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Chromones
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Vasodilator Agents