[7-fluoro-4-chromone-3-sulfur compounds]

Arch Pharm (Weinheim). 1994 Apr;327(4):267-9. doi: 10.1002/ardp.19943270413.
[Article in German]

Abstract

The novel 7-fluoro-4-chromone-3-sulfur compounds 5-12 were synthesized from the sulfinic acid 4, which can be obtained from the enaminone 3 and thionyl chloride. Especially the Flosequinane-like sulfoxide 12 was prepared and the vasodilating activity was evaluated in isolated ring segments of rat aorta.

Publication types

  • English Abstract

MeSH terms

  • Animals
  • Aorta, Thoracic / drug effects
  • Chromones / chemical synthesis*
  • Chromones / pharmacology
  • In Vitro Techniques
  • Male
  • Muscle, Smooth, Vascular / drug effects
  • Rats
  • Rats, Wistar
  • Vasodilator Agents / chemical synthesis*
  • Vasodilator Agents / pharmacology

Substances

  • Chromones
  • Vasodilator Agents