Antiplatelet constituents of formosan Rubia akane

M I Chung; S J Jou; T H Cheng; C N Lin; F N Ko; C M Teng

doi:10.1021/np50104a020

Antiplatelet constituents of formosan Rubia akane

J Nat Prod. 1994 Feb;57(2):313-6. doi: 10.1021/np50104a020.

Authors

M I Chung¹, S J Jou, T H Cheng, C N Lin, F N Ko, C M Teng

Affiliation

¹ Natural Products Research Center, Kaohsiung Medical College, Taiwan, Republic of China.

PMID: 8176404
DOI: 10.1021/np50104a020

Abstract

A known steroid, in addition to triterpenoids, anthraquinones, naphthalenes and a new anthraquinone glycoside, xanthopurpurin 3-O-beta-D-glucoside, were isolated from the roots of Rubia akane grown in Taiwan. Mollugin, a naphthohydroquinone, showed strong inhibition of arachidonic acid (AA)-induced and collagen-induced platelet aggregation. In contrast, 2-methyl-1,3,6-trihydroxyl-9,10-anthraquinone, xanthopurpurin 3-O-beta-D-glucoside, and xanthopurpurin showed mainly strong inhibition of collagen-induced platelet aggregation.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Arachidonic Acid / antagonists & inhibitors
Collagen / antagonists & inhibitors
In Vitro Techniques
Magnetic Resonance Spectroscopy
Mass Spectrometry
Plants, Medicinal / chemistry*
Platelet Aggregation / drug effects
Platelet Aggregation Inhibitors / isolation & purification*
Platelet Aggregation Inhibitors / pharmacology
Rabbits
Spectrophotometry, Infrared
Spectrophotometry, Ultraviolet
Taiwan
Thrombin / antagonists & inhibitors

Substances

Platelet Aggregation Inhibitors
Arachidonic Acid
Collagen
Thrombin