Abstract
The three-dimensional structures of myosin subfragment 1 (S1), gelsolin segment 1 complexed with alpha-actin, villin fragment 14T, Acanthamoeba profilin-I, and bovine profilin complexed with beta-actin were completed last year. Together, they expand our understanding of the structural organization of actin-binding proteins. In addition, the segment 1 and bovine profilin complexes provide atomic-level descriptions of their interfaces with actin.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Actins / chemistry*
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Actins / metabolism
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Amino Acid Sequence
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Animals
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Binding Sites
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Carrier Proteins / chemistry
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Carrier Proteins / metabolism
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Gelsolin / chemistry
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Gelsolin / metabolism
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Humans
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Microfilament Proteins / chemistry*
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Microfilament Proteins / metabolism
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Models, Molecular
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Molecular Sequence Data
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Myosin Subfragments / chemistry
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Myosin Subfragments / metabolism
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Protein Structure, Secondary*
Substances
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Actins
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Carrier Proteins
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Gelsolin
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Microfilament Proteins
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Myosin Subfragments
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villin