Interleukin-3 stimulates prostaglandin E2 release by human fetal membranes at term gestation

N Pasetto; C Ticconi; A Zicari; G Pontieri; E Piccione

doi:10.1016/0165-0378(93)90057-o

Interleukin-3 stimulates prostaglandin E2 release by human fetal membranes at term gestation

J Reprod Immunol. 1993 Nov;25(2):185-8. doi: 10.1016/0165-0378(93)90057-o.

Authors

N Pasetto¹, C Ticconi, A Zicari, G Pontieri, E Piccione

Affiliation

¹ Department of Obstetrics and Gynecology, II University of Rome, Italy.

PMID: 8164197
DOI: 10.1016/0165-0378(93)90057-o

Abstract

The effect of interleukin-3 (IL-3) on prostaglandin E2 (PGE2) release by human fetal membranes at term gestation was evaluated. It was found that interleukin-3 stimulates in vitro prostaglandin E2 release by these gestational tissues, suggesting that interleukin-3 might be involved in the regulation of arachidonic acid metabolism in the fetal membranes.

MeSH terms

Arachidonic Acid / metabolism
Dinoprostone / metabolism*
Dose-Response Relationship, Drug
Extraembryonic Membranes / drug effects*
Extraembryonic Membranes / immunology
Extraembryonic Membranes / physiology
Female
Gestational Age
Humans
In Vitro Techniques
Interleukin-3 / administration & dosage
Interleukin-3 / pharmacology*
Labor, Obstetric / physiology
Pregnancy
Protein Kinase C / metabolism

Substances

Interleukin-3
Arachidonic Acid
Protein Kinase C
Dinoprostone