Abstract
In a virus particle, the genome is highly condensed and protected by proteins and membrane bilayers. Before it can be replicated in a new host cell, uncoating must take place. Recent studies on enveloped and nonenveloped animal viruses indicate that uncoating occurs through complex, multistep processes triggered by virus-host-cell interactions.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Capsid / metabolism
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Cytosol / microbiology
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Endocytosis
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Humans
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Hydrogen-Ion Concentration
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Peptide Hydrolases / metabolism
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Receptors, Virus / metabolism
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Virus Physiological Phenomena*
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Virus Replication
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Viruses / genetics
Substances
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Receptors, Virus
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Peptide Hydrolases