Antimicrobial activity of natural and semisynthetic diterpenoids from Sideritis spp

M E Rodríguez-Linde; R M Díaz; A García-Granados; J Quevedo-Sarmiento; E Moreno; M R Onorato; A Parra; A Ramos-Cormenzana

Antimicrobial activity of natural and semisynthetic diterpenoids from Sideritis spp

Microbios. 1994;77(310):7-13.

Authors

M E Rodríguez-Linde¹, R M Díaz, A García-Granados, J Quevedo-Sarmiento, E Moreno, M R Onorato, A Parra, A Ramos-Cormenzana

Affiliation

¹ Department of Microbiology, University of Granada, Spain.

PMID: 8159128

Abstract

The antimicrobial activity of 22 natural diterpenoids of endemic Sideritis from Eastern Andalusia (Spain) is described. Only ent-kaur-16-ene foliol and ent-beyer-15-ene isopusillatriol proved to be active towards Gram-positive and acid-fast bacteria. The introduction of a ketonic group at C-15 on ent-kaur-16-enic systems produced a remarkable degree of activity.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-Bacterial Agents
Anti-Infective Agents / chemistry
Anti-Infective Agents / pharmacology*
Candida albicans / drug effects
Diterpenes / chemistry
Diterpenes / pharmacology*
Gram-Positive Bacteria / drug effects*
Microbial Sensitivity Tests
Molecular Structure
Plants, Medicinal / chemistry*
Spain
Structure-Activity Relationship

Substances

Anti-Bacterial Agents
Anti-Infective Agents
Diterpenes