Heterogeneity of hematopoietic stem cells

Curr Opin Immunol. 1993 Apr;5(2):177-84. doi: 10.1016/0952-7915(93)90002-a.

Abstract

Hematopoietic stem cells are capable of multi-lineage differentiation to all blood cell types as well as self-renewal and radioprotection. Thy-1.1lo Lin-/lo Sca-1+ cells are a heterogeneous mixture of quiescent and self-renewing hematopoietic stem cells as well as multi-lineage expanding cells.

Publication types

  • Review

MeSH terms

  • Animals
  • Antigens, Differentiation / metabolism
  • Antigens, Surface / genetics
  • Cell Differentiation
  • Gene Rearrangement
  • Hematopoiesis
  • Hematopoietic Stem Cells / cytology*
  • Hematopoietic System / embryology
  • Hematopoietic System / growth & development
  • Immunophenotyping
  • Membrane Glycoproteins / genetics
  • Mice
  • Mice, Inbred Strains / genetics
  • Mice, Inbred Strains / immunology
  • Thy-1 Antigens

Substances

  • Antigens, Differentiation
  • Antigens, Surface
  • Membrane Glycoproteins
  • Thy-1 Antigens