Central catheter infection by Trichosporon beigelii after autologous blood stem cell transplantation. A case report and review of the literature

Haematologica. 1993 Jan-Feb;78(1):64-7.

Abstract

A case of localized Trichosporon beigelii infection is reported in a 40-year-old woman with Ph+ chronic granulocyte leukemia who underwent autologous blood stem cell transplantation. On day +14 after autograft, while severely neutropenic, she developed a local infection involving the soft tissues surrounding the central venous catheter (CVC) point of entry into the subclavian vein. Trichosporon beigelii was isolated from culture of the CVC tip; resolution occurred after removal of the CVC, neutrophil recovery and antifungal treatment with amphotericin B and 5-fluorocytosine. To our knowledge this is the first case of CVC localized infection from Trichosporon beigelii after transplantation.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adult
  • Antifungal Agents / therapeutic use
  • Blood Transfusion, Autologous*
  • Catheterization, Central Venous / adverse effects*
  • Combined Modality Therapy
  • Female
  • Hematopoietic Stem Cell Transplantation*
  • Humans
  • Immunocompromised Host
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive / complications
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive / therapy
  • Leukemia, Myeloid, Accelerated Phase / complications
  • Leukemia, Myeloid, Accelerated Phase / therapy
  • Mycoses / drug therapy
  • Mycoses / etiology*
  • Mycoses / microbiology
  • Trichosporon / isolation & purification*

Substances

  • Antifungal Agents