Linkage analysis of 19 French breast cancer families, with five chromosome 17q markers

Am J Hum Genet. 1993 Apr;52(4):754-60.

Abstract

Nineteen French breast and breast-ovarian cancer families were tested for linkage with five chromosome 17q markers. The five breast-ovarian cancer families as a group give positive evidence for linkage, whereas the 14 breast cancer-only families do not. Heterogeneity of linkage of breast and breast-ovarian cancers is significant in France and supports the existence of more than one susceptibility gene.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Breast Neoplasms / genetics*
  • Chi-Square Distribution
  • Chromosome Mapping / methods*
  • Chromosomes, Human, Pair 17*
  • Family Health
  • Female
  • France
  • Genetic Linkage
  • Genetic Markers
  • Genetic Predisposition to Disease
  • Genetic Variation
  • Humans
  • Lod Score
  • Male
  • Middle Aged
  • Neoplastic Syndromes, Hereditary / genetics
  • Ovarian Neoplasms / genetics
  • Pedigree
  • Polymorphism, Restriction Fragment Length
  • Proto-Oncogenes*

Substances

  • Genetic Markers