Induction of respiration-deficient mutants in Saccharomyces cerevisiae by chelerythrine

FEMS Microbiol Lett. 1994 Jul 1;120(1-2):87-91. doi: 10.1016/0378-1097(94)00180-4.

Abstract

Chelerythrine and sanguinarine, two structurally related benzo/c/phenanthridine alkaloids, prevented growth of yeast cells in medium containing either glucose or non-fermentable carbon sources. At concentrations permitting growth of the yeast Saccharomyces cerevisiae, chelerythrine, but not sanquinarine, induced cytoplasmic respiration-deficient mutants. The petite clones that were analysed exhibited suppressiveness and contained different fragments of the wild-type mitochondrial genome.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkaloids / pharmacology*
  • Anti-Bacterial Agents / pharmacology*
  • Benzophenanthridines
  • DNA, Mitochondrial / drug effects
  • Isoquinolines
  • Microbial Sensitivity Tests
  • Mutation / genetics*
  • Oxygen Consumption / drug effects
  • Oxygen Consumption / genetics*
  • Phenanthridines / pharmacology*
  • Saccharomyces cerevisiae / drug effects
  • Saccharomyces cerevisiae / genetics*
  • Saccharomyces cerevisiae / growth & development

Substances

  • Alkaloids
  • Anti-Bacterial Agents
  • Benzophenanthridines
  • DNA, Mitochondrial
  • Isoquinolines
  • Phenanthridines
  • sanguinarine
  • chelerythrine