[Contractility and energy metabolism in human myocardium in normal state and in various stages of cardiac insufficiency]

V H Shevchuk; S B Frantsuzova; N O Horchakova; O I Plyska; V V Babak; L L Arshynnykova; V V Lazoryshynets; V V Iakymovych

[Contractility and energy metabolism in human myocardium in normal state and in various stages of cardiac insufficiency]

Fiziol Zh (1978). 1993 Sep-Dec;39(5-6):18-23.

[Article in Ukrainian]

Authors

V H Shevchuk, S B Frantsuzova, N O Horchakova, O I Plyska, V V Babak, L L Arshynnykova, V V Lazoryshynets, V V Iakymovych

PMID: 8045312

Abstract

Contractile function and metabolism of byoptates of human myocardium were investigated in the control group and at early stages of heart failure development. Support of the myocardial contractile function at the early stage of the heart failure is provided by intensive use of macroergic phosphates and their insufficient resynthesis. At the late stages of myocardial failure deterioration of the heart muscle relaxation was observed as a result of disturbances in transport of high-ergic phosphates to the sites of their utilization.

Publication types

English Abstract

MeSH terms

Cardiac Output, Low / metabolism*
Cardiac Output, Low / physiopathology*
Creatine Kinase / metabolism*
Electric Stimulation
Energy Metabolism*
Heart / physiopathology*
Humans
In Vitro Techniques
Myocardial Contraction / physiology
Myocardium / metabolism*
Phosphocreatine / metabolism*

Substances

Phosphocreatine
Creatine Kinase