Constituents of euphorbiaceae 12. Comm. (1). Isolation and structure elucidation of four new cerebrosides from Euphorbia biglandulosa Desf

G Falsone; F Cateni; G Visintin; V Lucchini; H Wagner; O Seligmann

Constituents of euphorbiaceae 12. Comm. (1). Isolation and structure elucidation of four new cerebrosides from Euphorbia biglandulosa Desf

Farmaco. 1994 Mar;49(3):167-74.

Authors

G Falsone¹, F Cateni, G Visintin, V Lucchini, H Wagner, O Seligmann

Affiliation

¹ Department of Pharmaceutical Sciences, University of Trieste.

PMID: 8043167

Abstract

Four new cerebrosides 4-6 were isolated from the latex of Euphorbia biglandulosa Desf. and their structures determined. Normal and reverse-phase flash chromatography was effective for the isolation of the cerebrosides, and FAB-MS spectrometry, 1H-NMR, 13C-NMR, DQF-COSY and HMQC experiments and chemical reactions were useful in elucidating their structure. EI-MS of the dimethyl disulfide derivatives of the long chain bases and glucosphingoside-heptaacetates was decisive for the determination of the double bond position on the long chain parts.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cerebrosides / chemistry*
Chromatography
Latex / chemistry
Magnetic Resonance Spectroscopy
Plants, Medicinal / chemistry*
Spectrometry, Mass, Fast Atom Bombardment

Substances

Cerebrosides
Latex