Abstract
1. In the SHR juxtamedullary nephron preparation, the increase of the perfusion pressure from 80 to 160 mmHg increased the diameters of arcuate arteries but produced a pressure-dependent contraction of the afferent arterioles, a response that can account for renal autoregulation. 2. The pressure-induced contractions of the afferent arterioles were abolished by 1 microM nifedipine and by 10 microM furosemide, suggesting that the autoregulatory responses are mainly mediated by tubuloglomerular mechanisms and can be abolished by calcium antagonists.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Arterioles / drug effects
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Arterioles / physiology
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Blood Pressure / drug effects
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Blood Pressure / physiology
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Furosemide / pharmacology
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In Vitro Techniques
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Kidney Medulla / blood supply*
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Kidney Medulla / drug effects
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Kidney Medulla / physiology
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Muscle Contraction / drug effects
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Muscle Contraction / physiology
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Muscle, Smooth, Vascular / drug effects
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Muscle, Smooth, Vascular / physiology*
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Nephrons / blood supply
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Nephrons / drug effects
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Nephrons / physiology
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Nifedipine / pharmacology
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Norepinephrine / pharmacology
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Perfusion
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Pressure
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Rats
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Rats, Inbred SHR
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Regional Blood Flow / drug effects
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Regional Blood Flow / physiology
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Renal Circulation / drug effects
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Renal Circulation / physiology
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Serotonin / pharmacology
Substances
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Serotonin
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Furosemide
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Nifedipine
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Norepinephrine