The effect of 72 epileptic patients treated with alkaline extract of Euphorbia fisheriana (EF) was reported. 22 of them with intractable epilepsy were compared with the treatment of both single-blind and placebo. The results showed that the total effective rate with EF was 78%, its marked effective rate was 42% and the effective rate 36%. The epileptic patients reduced their frequency of seizures significantly (P < 0.05), while the effective rate of 22 epileptic patients with single-blind treatment was 59%, and that with placebo was 32%. There was a significant difference between the two groups (P < 0.05). The active principle of Euphorbia fisheriana was Euphorbia alkaloid. There was no obvious adverse effect in clinical observation. It is considered that Euphorbia fisheriana is rich in resource, cheap, and with marked anticonvulsant effect.