Pharmacokinetic results on naproxen prodrugs based on poly(ethyleneglycol)s

E Ranucci; L Sartore; I Peroni; R Latini; R Bernasconi; P Ferruti

doi:10.1163/156856294x00275

Pharmacokinetic results on naproxen prodrugs based on poly(ethyleneglycol)s

J Biomater Sci Polym Ed. 1994;6(2):141-7. doi: 10.1163/156856294x00275.

Authors

E Ranucci¹, L Sartore, I Peroni, R Latini, R Bernasconi, P Ferruti

Affiliation

¹ Dipartimento di Ingegneria Meccanica, Università di Brescia, Italy.

PMID: 7947480
DOI: 10.1163/156856294x00275

Abstract

Five prodrugs of S(+)-2-(6-methoxy-2-naphthyl)propionic acid (naproxen), in which the drug was bound by ester linkages to diethyleneglycol (I), triethyleneglycol (II), octanediol (III), butyl-triethyleneglycol (IV), and butyl-tetraethyleneglycol (V), respectively, were prepared and tested for their pharmacokinetic properties after oral administration. It was found that bioavailabilities decreased in the order, and in all cases were lower than that of the free drug.

Publication types

Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

Administration, Oral
Animals
Drug Carriers
Male
Molecular Structure
Naproxen / administration & dosage
Naproxen / blood
Naproxen / pharmacokinetics*
Polyethylene Glycols*
Prodrugs / administration & dosage
Prodrugs / chemical synthesis
Prodrugs / pharmacokinetics*
Rats
Rats, Sprague-Dawley
Structure-Activity Relationship

Substances

Drug Carriers
Prodrugs
Polyethylene Glycols
Naproxen