Long-term follow up in type A insulin resistant syndrome treated by insulin-like growth factor I

Arch Dis Child. 1994 Aug;71(2):144-6. doi: 10.1136/adc.71.2.144.

Abstract

Insulin-like growth factor I (IGF-I) is a useful therapeutic agent in insulin resistant diabetes mellitus due to insulin receptor disease because of its hypoglycaemic effects through the IGF-I receptor. A girl with typical type A insulin resistant syndrome was treated with IGF-I for two years and the treatment was effective in ameliorating hyperglycaemia. Overproduction of testosterone in polycystic ovaries was aggravated with this treatment, however. Therefore, IGF-I treatment may be used for glycaemic control but with caution because of its possible side effect of aggravating hyperandrogenism in these patients.

Publication types

  • Case Reports

MeSH terms

  • Acanthosis Nigricans / metabolism*
  • Blood Glucose / metabolism
  • Child
  • Diabetes Mellitus / metabolism*
  • Erythrocytes / metabolism
  • Female
  • Fibroblasts / metabolism
  • Follow-Up Studies
  • Humans
  • Insulin / metabolism
  • Insulin Resistance*
  • Insulin-Like Growth Factor I / therapeutic use*
  • Lymphocyte Activation
  • Lymphocytes / metabolism
  • Polycystic Ovary Syndrome / metabolism*
  • Receptor, Insulin / metabolism
  • Syndrome
  • Testosterone / biosynthesis*
  • Testosterone / blood

Substances

  • Blood Glucose
  • Insulin
  • Testosterone
  • Insulin-Like Growth Factor I
  • Receptor, Insulin