Abstract
Both interleukin-1 alpha (IL-1 alpha) and interleukin-1 beta (IL-1 beta) are powerful stimulators of bone resorption in vivo and in vitro. Interleukin-1 receptor antagonist (IL-1ra) binds to many interleukin-1 receptors. It does not activate the receptor and effectively blocks the action of IL-1 alpha and IL-1 beta. In this study, human recombinant IL-1ra, at 100-fold excess, was found to block bone resorption in cultured mouse calvaria due to IL-1 beta but not IL-1 alpha. These observations may be explained by differential affinities of receptors for IL-1 alpha, IL-1 beta and rhIL-1ra on target bone cells.
Publication types
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Comparative Study
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Analysis of Variance
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Animals
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Bone Resorption / chemically induced
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Bone Resorption / prevention & control*
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Cells, Cultured
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Humans
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Interleukin 1 Receptor Antagonist Protein
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Interleukin-1 / toxicity*
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Mice
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Osteoclasts / drug effects*
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Parathyroid Hormone / toxicity
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Peptide Fragments / toxicity
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Receptors, Interleukin-1 / antagonists & inhibitors*
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Recombinant Proteins / pharmacology
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Recombinant Proteins / therapeutic use
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Sialoglycoproteins / pharmacology
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Sialoglycoproteins / therapeutic use*
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Teriparatide
Substances
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IL1RN protein, human
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Il1rn protein, mouse
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Interleukin 1 Receptor Antagonist Protein
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Interleukin-1
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Parathyroid Hormone
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Peptide Fragments
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Receptors, Interleukin-1
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Recombinant Proteins
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Sialoglycoproteins
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Teriparatide