The PGPA gene of Leishmania major mediates antimony (SbIII) resistance by decreasing influx and not by increasing efflux

Mol Biochem Parasitol. 1994 Nov;68(1):145-9. doi: 10.1016/0166-6851(94)00154-5.

Authors

H L Callahan¹, W L Roberts, P M Rainey, S M Beverley

Affiliation

¹ Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115.

PMID: 7891738
DOI: 10.1016/0166-6851(94)00154-5

No abstract available

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

MeSH terms

ATP Binding Cassette Transporter, Subfamily B, Member 1 / genetics
ATP Binding Cassette Transporter, Subfamily B, Member 1 / metabolism
Animals
Antimony / pharmacokinetics
Antimony / pharmacology*
Drug Resistance / genetics
Genes, Protozoan*
Ion Transport / genetics
Leishmania major / drug effects*
Leishmania major / genetics*
Leishmania major / metabolism
Temperature
Transfection

Substances

ATP Binding Cassette Transporter, Subfamily B, Member 1
Antimony

Grants and funding